Schizophrenia with auditory hallucinations
Conditions
Interventions
rTMS-alone group:rTMS
tDCS-alone group:tDCS
Combined rTMS+tDCS group:rTMS+tDCS
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosis of schizophrenia according to the International Classification of Diseases, 10th Revision (ICD-10); 2.Age between 18 and 55 years, with a disease duration of >= 2 years and stable medication dosage for at least one month; 3. Persistent auditory hallucinations lasting for >= 6 months; 4. Receiving antipsychotic medication at a stable dose for at least 4 weeks but still exhibiting treatment-resistant AVH (defined as an Auditory Hallucination Rating Scale [AHRS] score >= 4, indicating at least moderate severity); 5. Written informed consent obtained from the patient and/or their legal guardian.
Exclusion criteria
Exclusion criteria: 1.Presence of severe or unstable organic diseases, acute brain injury, or infection; 2.Skin lesions or impaired integrity at the electrode placement sites, or known allergy to electrode gel or adhesive materials; 3. A score = 3 on the suicide item of the 17-item Hamilton Depression Rating Scale (HAMD-17); 4. Concurrent participation in another clinical trial; 5. Prior exposure to any neurostimulation therapy (including electroconvulsive therapy, rTMS, tDCS, or transcranial alternating current stimulation) within the past three months; 6. Presence of any implanted medical or metallic device (such as a cochlear implant, cardiac pacemaker, deep brain stimulator, or intracranial metal); 7. Any other condition deemed by the investigators to make the participant unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anxiety ;The degree of alleviation of auditory hallucinations;The functional connectivity strength between the temporoparietal junction (TPJ) and the dorsolateral prefrontal cortex (DLPFC);The degree of remission of schizophrenia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression; | — |
Countries
China
Contacts
Public ContactLi Xiao
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed