cyclopropofol
Conditions
Interventions
Experimental group:Using an improved Dixon sequential method to determine the dose of cyclosporine that inhibits gastroscopy placement response. The initial dose of cyclosporine is 0.4mg/kg, with a do
If the previous case has a negative reaction, the next case will have one dose gradient reduced.
Sponsors
Sichuan Provincial Women’s and Children’s Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 12 Years
Inclusion criteria
Inclusion criteria: Children aged 3-12 years, classified as ASA I or II by the American Society of Anesthesiologists, with a BMI between 18 and 25 kg/m², undergoing elective gastroscopy.
Exclusion criteria
Exclusion criteria: 1. Children with heart, lung, liver, or kidney dysfunction, severe anemia, or a history of metabolic diseases; 2. those with potential difficult airways, acute upper respiratory tract infection not cured within one week, asthma attack period, or a history of neuropsychiatric disorders; 3. children known to be allergic to emulsions or opioids; 4. those who took any sedatives before surgery or participated in other drug clinical trials within 3 months before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50;ED95; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate, HR;mean arterial pressure, MAP;SpO2 ;Injection pain;Hypoxemia;Low blood pressure;Bradycardia;Laryngospasm;Bronchospasm; | — |
Countries
China
Contacts
Public ContactLi Lei
Sichuan Provincial Women’s and Children’s Hospital
Outcome results
None listed