Ischemia-reperfusion injury
Conditions
Interventions
Dexmedetomidine group (DEX):A loading dose of 0.5 µg/kg was administered over 10 minutes before the start of surgery, followed by a maintenance dose of 0.5 µg/kg/h, which was discontinued 30 minutes b
Control group:Administer saline
Sponsors
Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Signed informed consent form; (2)18 years < Patient age <=75 years , regardless of gender; (3) American Society of Anesthesiologists (ASA) classification I or II; (4) Preoperative Child-Pugh score A or B; (5) Patients scheduled for elective liver tumor resection; (6) Patients expected to undergo intraoperative hepatic portal occlusion.
Exclusion criteria
Exclusion criteria: (1) Emergency surgery; (2) Sick sinus syndrome, severe sinus bradycardia (heart rate < 50 bpm), second-degree or higher atrioventricular block without a pacemaker; (3) Known allergy to the study drug; (4) Patient refuses to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ALT, AST; | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15; | — |
Countries
China
Contacts
Public ContactYun Zhu
Fudan University Shanghai Cancer Center (Pudong Campus)
Outcome results
None listed