HIV
Conditions
Interventions
DTG+2NRTIS(cohort 2):DTG+2NRTIS
DTG+3TC(cohort 1):DTG+3TC
DTG+2NRTI(cohort 1):DTG+2NRTI
Sponsors
Beijing Ditan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: Cohort 1 inclusion criteria: 1. Confirmed HIV infection, weight >= 20 kg, under 18 years old; 2. No history of treatment failure, receiving a stable ART regimen for >= 6 months, and HIV RNA = 20 kg, under 18 years old; 2. Previously switched to a PI/r-based regimen due to treatment failure, regardless of current viral suppression or failure. Failure is defined as HIV RNA >= 1000 copies/mL in the past 6 months or >= 200 copies/mL on two consecutive tests; No severe opportunistic infections or malignancies; 3. Informed consent signed by guardian;
Exclusion criteria
Exclusion criteria: 1. Combined severe liver and kidney dysfunction (ALT/AST >5×ULN, eGFR <30 mL/min); 2. Known allergy or intolerance to DTG or 3TC/NRTIs; 3. Concurrent severe mental illness; 4. Any condition that the investigator believes may endanger the safety of the subject or affect compliance with the study protocol; 5. Subjects with a history of resistance to DTG.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HIV RNA load; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete Blood Count;Height and weight;CD4 counts;Blood Biochemistry; | — |
Countries
China
Contacts
Public ContactHongxin Zhao
Beijing Ditan Hospital, Capital Medical University
Outcome results
None listed