Chronic Kidney Disease
Conditions
Interventions
Treatment Group:Basic Treatment + Shouhui Tongbian Capsule
Control Group:Basic Treatment
Sponsors
Affiliated Hospital of Nanjing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with CKD stages 3-5 according to the KDIGO guidelines; 2. Aged between 18 and 80 years, regardless of gender; 3. Adequate control of conditions such as infection, acidosis, electrolyte disturbances, hypertension, and hyperlipidemia; 4. Voluntary participation in this study with signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Chronic kidney disease caused by definite secondary factors, such as lupus nephritis, Henoch-Schönlein purpura nephritis, renal damage due to systemic small-vessel vasculitis, or myeloma nephropathy. 2. Acute kidney injury caused by various reasons. 3. Use of medications affecting intestinal flora (e.g., antibiotics or probiotics) within the past month. 4. Gastrointestinal symptoms such as abdominal pain or diarrhea (stool frequency >= 3 times/day, watery stools) within the past 2 weeks. 5. History of abdominal surgery (except appendectomy), or any intestinal disease or neurological disorder causing defecation abnormalities, such as ulcerative colitis, irritable bowel syndrome, multiple sclerosis, or spinal cord injury. 6. Combined with liver dysfunction (ALT or AST >= 31 U/L), or a history of liver disease, or a history of liver injury or family history associated with Polygonum multiflorum preparations. 7. Complicated with consciousness disorders, acute infections, severe cardiopulmonary or hematopoietic system diseases, severe malnutrition, malignant tumors, or any other severe disease affecting survival. 8. Presence of primary bone metabolic diseases, primary parathyroid diseases, or history of parathyroid surgery, kidney transplantation, or other conditions that may interfere with the evaluation of efficacy indicators. 9. Psychiatric disorders that preclude cooperation, lactation, or pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glomerular filtration rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine;Serum urea nitrogen;Serum uric acid;Serum cystatin C;Hemoglobin; | — |
Countries
China
Contacts
Public ContactZhou Enchao
Nanjing University of Chinese Medicine
Outcome results
None listed