Acute kidney injury after robot-assisted partial nephrectomy
Conditions
Interventions
Group Norepinephrine (NE):Dilute 2mg of norepinephrine with 5% glucose solution to 500ml to obtain a concentration of 4µg /ml.Beginning from anesthesia induction, administer a 1-2 ml bolus or infuse 4
Group Phenylephrine (PE):Dilute 10mg of norepinephrine with 5% glucose solution to 250ml to obtain a concentration of 40µg /ml.Beginning from anesthesia induction, administer a 1–2 ml bolus or infuse
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 years or older, scheduled to undergo elective robot-assisted partial nephrectomy under general anesthesia; 2. Patients with unilateral renal tumor occupation and normal contralateral renal function; 3. American Society of Anesthesiologists Physical Status (ASA-PS) classification of I-III; 4. Written informed consent has been obtained.
Exclusion criteria
Exclusion criteria: 1. Patients with multiple renal cell carcinomas, distant metastasis, and lymph node metastasis; 2. Patients with chronic kidney disease, end-stage renal disease requiring renal replacement therapy, or a history of major urological surgery (e.g., renal transplantation, nephrectomy, or partial nephrectomy); 3. Patients who received preoperative infusion of vasoactive drugs such as norepinephrine or phenylephrine; 4. Patients with severe cardiac disease, severe hepatic failure, hematological disorders, other malignancies, or conditions deemed by investigators as unsuitable for the study; 5. Pregnant or obese patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative AKI; | — |
Secondary
| Measure | Time frame |
|---|---|
| The highest creatinine level during postoperative hospital stay, the incidence of moderate to severe AKI, and the stage of acute kidney injury (KDIGO stage);Cumulative intraoperative vasopressor dose;Postoperative systemic immune-inflammation index(SII: Platelet count × neutrophil-to-lymphocyte ratio);Need for vasoactive medication during the postoperative hospital stay;Intraoperative carbon dioxide pneumoperitoneum duration, intraoperative fluid infusion volume, intraoperative urine output, operation duration, intraoperative hypertension, postoperative hospital stay;Quality of life score 24 hours after the operation; | — |
Countries
China
Contacts
Public ContactXu Guanghong
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed