insulin resistance
Conditions
Interventions
PCOS + IR group:none
PCOS without IR group:none
non-PCOS + IR group:none
healthy control group:none
IR improvement group:none
Sponsors
The Third People 's Hospital of Chengdu
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–45 years; 2. Regular or predictable menstruation; 3. Agree to undergo endometrial biopsy; 4. Sign informed consent; 5. PCOS IR group: meet Rotterdam diagnostic criteria (=2 items); HOMA-IR = 2.5; 6. PCOS non-IR group: same as above, but HOMA-IR < 2.5; no glucose or lipid metabolism abnormalities; 7. Non-PCOS IR group: do not meet PCOS diagnostic criteria; HOMA-IR = 2.5; 8. Healthy control group: no PCOS manifestations; normal HOMA-IR; normal metabolic indicators;
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding women; 2. Use of hormones or metabolic intervention drugs in the past 3 months (without standard treatment); 3. Combined with uterine fibroids, endometriosis, adenomyosis, etc.; 4. Systemic autoimmune diseases, infections, or malignant tumors; 5. Unable to cooperate with follow-up or refuse to sign the informed consent form;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Epithelial cell ratio;natrural killer cells ratio;Proportion of stromal cells; | — |
Secondary
| Measure | Time frame |
|---|---|
| ESR1;PAEP;ROBO2;COL1A2;CD44; | — |
Countries
China
Contacts
Public ContactLI Junqiang
The Third People 's Hospital of Chengdu
Outcome results
None listed