Oral leukoplakia
Conditions
Interventions
Single-arm Cohort:CO2 laser therapy: continuous pulse mode, power 10-15W, mucosa-head distance 15-20mm, head focal length 125mm, laser exposure time 20s, spot diameter 0.3mm, energy 4244 J/cm^2, resec
postoperative use of chlorhexidine acetate to prevent infection, compound chamomile lidocaine gel for pain relief.
Sponsors
The Third Affiliated Hospital of Air Force Medical University of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with clinically diagnosed oral leukoplakia presenting predominantly as white plaques, and pathologically confirmed as oral leukoplakia without epithelial dysplasia by histopathological examination. 2. Lesions with well-defined borders and an area no larger than 30×30 mm^2. 3. Age between 18 and 70 years old, with normal mental and intellectual status. 4. Normal vital signs (blood pressure, pulse, respiration), and normal results in routine examinations including blood routine, blood glucose, coagulation function, hepatitis B, hepatitis C, syphilis, and HIV tests.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women. 2. Patients with hypersensitivity to both articaine and lidocaine. 3. Patients with severe systemic diseases (e.g., cardiovascular diseases, diabetes mellitus, liver diseases, renal insufficiency, tumors, etc.). 4. Patients taking long-term oral contraceptives or steroids. 5. Patients who are not suitable for surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Toluidine blue and fluorescence staining;Recurrence rate after treatment;Histopathological assessment (inflammatory and proliferative markers); | — |
Countries
China
Contacts
Public ContactWang Yuanyuan
The Third Affiliated Hospital of Air Force Medical University, PLA
Outcome results
None listed