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Neuropsychological Mechanisms of Early Life Adversity on Anhedonia: A Multimodal Longitudinal Study

Neuropsychological Mechanisms of Early Life Adversity on Anhedonia: A Multimodal Longitudinal Study

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600120275
Enrollment
Unknown
Registered
2026-03-11
Start date
2025-11-25
Completion date
Unknown
Last updated
2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anhedonia

Interventions

Dorsolateral prefrontal cortex (dlPFC) intervention group:Anodal stimulation was administered to the left dorsolateral prefrontal cortex (dlPFC) at 2mA. A total of 10 sessions were administered, once
Dorsomedial prefrontal cortex (dmPFC) intervention group.:Anodal stimulation was applied to the dorsomedial prefrontal cortex (dmPFC) at 2mA. A total of 10 sessions were administered, once daily for 1
Sham stimulation group:The sham stimulation group followed the same protocol as the intervention groups, except that the simulated current was gradually increased to 2mA during the initial 30s and ret
High anhedonia group:Wearing EEG equipment, participants completed a social reward processing task and a social emotion regulation task.
Low anhedonia group:Wearing EEG equipment, participants completed a social reward processing task and a social emotion regulation task.

Sponsors

Southwest University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 28 Years

Inclusion criteria

Inclusion criteria: 1. Current students at Southwest University, aged 18–28 years; 2.One of the inclusion criteria: individuals with high levels of anhedonia.

Exclusion criteria

Exclusion criteria: 1. had a confirmed diagnosis of bipolar disorder, schizophrenia, autism spectrum disorder, or other psychiatric disorders; 2. had significant physical illnesses, a family history of psychiatric disorders among first-degree relatives, organic brain injury, substance dependence, contraindications for EEG; 3. a history of neurological diseases (e.g., epilepsy, stroke, traumatic brain injury).

Design outcomes

Primary

MeasureTime frame
P300 Wave;Contingent Negative Variation, CNV;Early Posterior Negativity, EPN;Late Positive Potential, LPP;N200 at the Parietal Midline Area;The Temporal Experience of Pleasure Scale;Snaith-Hamilton Pleasure Scale;Childhood Trauma Ques- tionnaire,emotional abuse;Parental Psychological Control Scale, PPCS;Parental Bonding Instrument, PBI;

Secondary

MeasureTime frame
Patient Health Questionnaire-9 items, PHQ-9;

Countries

China

Contacts

Public ContactBing Cao

Faculty of Psychology, Southwest University

bingcao@swu.edu.cn+86 157 0239 6119

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 20, 2026