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Multimodal Intervention Study for Cognitive Function Improvement in Mild Cognitive Impairment Populations

Multimodal Intervention Efficacy of Digital Serious Game Systems: A Social Work Intervention Study on Cognitive Function Enhancement in MCI Populations from a "Whole Person-Environment" Perspective

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600120272
Enrollment
Unknown
Registered
2026-03-11
Start date
2026-03-15
Completion date
Unknown
Last updated
2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild cognitive impairment, MCI

Interventions

Group 1: Integrated Intervention Group (Body + Mind + Social) :Receives the full "Lighting System" intervention. Core intervention group. Tests whether the full "whole-person-environment" perspective
Group 2: Whole-Person Group (Body + Mind) :Receives physical exercise from the "Body System" plus training in "Cognitive Training Games." Core control group. Key comparison with Group 1 to isolat
Group 3: Single Environmental Group (Social Only) :Receives only group activities involving "social interaction." Tests the independent effect of pure "environmental" intervention (social modality
Group 4: Active Control Group :Receives a non-specific intervention, such as simple electronic games (card games, puzzles), health lectures, etc. Shared baseline with the first three groups.

Sponsors

School of Social Development, East China Normal University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
55 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age between 55 and 75 years; 2. Subjective cognitive decline (SCD-Q positive) reported by the participant or an informed source; 3. Typically scores below 3 on the AD8; 4. Owns and can operate a smartphone (Android or iOS) with basic proficiency; 5. Sufficient vision, hearing (corrective devices permitted), and language ability to complete tests and interventions; 6. Voluntarily participates with full understanding of the study, and provides signed written informed consent by the subject and/or family member.

Exclusion criteria

Exclusion criteria: 1. Diagnosed dementia (Clinical Dementia Rating [CDR] >= 1, Mini-Mental State Examination [MMSE] < 17, or Montreal Cognitive Assessment [MoCA] < 18); 2. Other severe neurological disorders significantly impairing cognition (e.g., Parkinson's disease, severe post-stroke cognitive impairment, traumatic brain injury); 3. Severe uncontrolled psychiatric disorders (major depressive disorder, schizophrenia, bipolar disorder); 4. Severe visual, auditory, or motor impairments preventing completion of interventions and assessments; 5. Recent participation (within 3 months) in other cognitive intervention or drug clinical trials; 6. Long-term use of medications significantly affecting cognitive function (e.g., high-dose sedatives) that cannot be stabilized during the study period.

Design outcomes

Primary

MeasureTime frame
MOCA(Montreal Cognitive Assessment) Score;

Secondary

MeasureTime frame
QOL-AD(Quality of Life-Alzheimer’s Disease) Score;Lubben Social Network Scale Brief( LSNS-6 ) Score;

Countries

China

Contacts

Public ContactChenxi Huang

School of Social Development, East China Normal University

cxhuang@soci.ecnu.edu.cn+86 137 6498 1081

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 20, 2026