None
Conditions
Interventions
L-group:In Group L, the remifentanil infusion rate was regulated according to the PTi monitoring results from the HXD-I Multifunctional Monitor, with the PTI maintained within the target range of 45–5
D-group:In Group D, the remifentanil infusion rate was adjusted based on the patients' vital signs, the intensity of surgical stimulation, and the clinicians’ clinical experience.
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years. 2.American Society of Anesthesiologists physical status classification ?-? . 3.Scheduled for elective knee arthroscopy under general anesthesia.
Exclusion criteria
Exclusion criteria: 1.Ischemic heart disease, uncontrolled hypertension, hepatic or renal insufficiency. 2.Chronic use of opioid analgesics, sedatives or antidepressants. 3.A history of schizophrenia, epilepsy, Parkinson's disease or myasthenia gravis. 4.Contraindications to tourniquet use (e.g., peripheral vascular disease, peripheral neuropathy). 5.Tourniquet inflation time of less than 30 minutes or more than 120 minutes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative incidence of tourniquet-induced hypertension ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative hypotension incidence rate;Administration status of intraoperative vasoactive drugs;NRS pain scores preoperatively and at 1, 6, 12, and 48 hours postoperatively;Quality of Recovery Scores preoperatively and at 24 hours postoperatively;Consumption of analgesic drugs within 48 hours postoperatively;Postoperative nausea and vomiting, dizziness, and psychiatric-related adverse effects; | — |
Countries
China
Contacts
Public ContactChen Lijian
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed