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Cell typing - intestinal microbiota interaction guides clinical targeted intervention for ulcerative colitis

Research on the disease pattern characteristics and targeted intervention strategies of ulcerative colitis based on the precise analysis of the interaction between intestinal epithelial cell molecular-metabolic subtypes and intestinal flora

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600120264
Enrollment
Unknown
Registered
2026-03-11
Start date
2026-03-16
Completion date
Unknown
Last updated
2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative colitis

Interventions

Active to long-term remission type(Part One of the Study):None
Chronic recurrence type(Part One of the Study):None
Continuous activity type (Part One of the Study):None
Verification Cohort (Part Two of the Study):None

Sponsors

Peking Union Medical College Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. The patient was diagnosed with ulcerative colitis by endoscopy and histopathology (meeting the ECCO diagnostic criteria); 2. Age: 18 to 70; 3. Have a complete willingness to follow up and collect samples; 4. Be able to accept at least 3 follow-ups with intervals of more than 3 months; 5. Sign informed consent,

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating women; 2. Patients with other types of IBD (such as Crohn's disease), intestinal malignancies, autoimmune diseases, etc.; 3. Patients who are unable to undergo regular follow-up.

Design outcomes

Primary

MeasureTime frame
Improved MAYO score;ROC curve;AUC;Accuracy rate;Sensitivity;Specificity;Positive/negative predictive value;FI score;

Secondary

MeasureTime frame
Ulcerative Colitis Endoscopic Index of Severity(UCEIS) Score;

Countries

China

Contacts

Public ContactLingjuan Jiang

Peking Union Medical College Hospital, Beijing

irisjlj@163.com+86 185 0195 9190

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 20, 2026