Transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL)
Conditions
Interventions
HaNDL Patient:None
Sponsors
Hangzhou First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Fulfillment of the diagnostic criteria for HaNDL syndrome according to the International Classification of Headache Disorders, 3rd edition (ICHD-3).; 2. Presence of the classic triad of symptoms: headache, neurological deficits, and cerebrospinal fluid lymphocytosis.; 3. Aged between 18 and 65 years, irrespective of sex.; 4. Voluntary provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1. Confirmed intracranial infectious disease based on etiological examination.; 2. Positive for autoantibodies associated with autoimmune encephalitis.; 3. Neuroimaging evidence of vascular abnormalities or definite infarction.; 4. History of movement disorders such as essential tremor or Parkinson's disease.; 5. Comorbid severe cardiac, hepatic, or renal insufficiency, or malignancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association between basal ganglia enhancement and tremor onset timing;Dynamic relationship between cerebrospinal fluid inflammatory markers and tremor severity;Headache intensity;Tremor characteristics (frequency, amplitude, type, distribution); | — |
Countries
China
Contacts
Public ContactWang Hanbin
Hangzhou First People's Hospital
Outcome results
None listed