Epilepsy
Conditions
Interventions
Gold Standard:According to the latest standards of the International League Against Epilepsy (ILAE) in 2017, combined with a detailed clinical history and the results of video electroencephalogram (vE
Index test:Digital Molecular Diagnostic Kit for Children's Epilepsy Based on High Performance Liquid Chromatography-tandem Mass spectrometry (LC-MS/MS) (Purine)
Sponsors
Capital Children's Medical Center, Capital Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 18 Years
Inclusion criteria
Inclusion criteria: Case Group 1. Children with a first-time diagnosis of epilepsy based on the latest 2017 ILAE criteria, combined with detailed clinical history and video EEG (vEEG) findings; 2. Age >=3 years and =3 years and <18 years; 2. No history of clinical seizures and normal EEG findings; 3. Subjects and/or guardians signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of a high-purine diet within the past month (e.g., seafood, animal offal, etc.); 2. Current use of medications known to interfere with purine metabolism; 3. Children with severe physical comorbidities including renal dysfunction, systemic infection, malignant tumor, or immune system disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic performance of the five-indicator combined model in distinguishing epileptic children from healthy controls (AUC, sensitivity, specificity, positive predictive value, negative predictive value, accuracy);Optimal clinical decision threshold (Cut-off) of the diagnostic model; | — |
Countries
China
Contacts
Public ContactChen Qian
Capital Children's Medical Center, Capital Medical University
Outcome results
None listed