allergic rhinitis
Conditions
Interventions
Control Group (SCIT):Subcutaneous Immunotherapy (SCIT)
Experimental Group (ITIT):Intratonsillar Immunotherapy (ITIT)
Sponsors
The Fifth Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Voluntarily participate in the study and sign the informed consent form; 2.Aged 18 to 65 years old and meeting the diagnostic criteria for AR; 3.A history of moderate to severe AR, with a Total Nasal Symptom Score (TNSS) of >= 6 points in the recent 3 months; 4.Positive skin prick test (SPT); 5.Serum-specific IgE antibody test for HDM > 3.5 kU/L; 6.Poor response to standard pharmacotherapy; 7.Willing to receive AIT; 8.Able to communicate well with the researchers and comply with all trial requirements;
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating patients; 2.Patients with uncontrolled severe cardiovascular, hepatic, or renal diseases (e.g., unstable angina, NYHA Class III–IV heart failure, severe hepatic or renal dysfunction); 3.Patients taking medications that may interfere with immune responses; 4.Patients who received immunotherapy within the past 3 years prior to enrollment; 5.Patients with tonsillar atrophy in whom intratonsillar injection is technically difficult; 6.Patients with chronic tonsillitis, peritonsillar abscess, or moderate to severe palatine tonsillar hypertrophy who are not suitable for intratonsillar injection; 7.Patients who have undergone nasal surgery; 8.Patients with unreasonable expectations of treatment efficacy or poor compliance;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in TNSS (?TNSS);Mini-Rhinoconjunctivitis Quality of Life Questionnaire (Mini-RQLQ);Incidence of Adverse Events;Total Nasal Symptom Score Score (TNSS);Visual Analogue Scale for Nasal Symptoms Score (VAS);Combined Symptom and Medication Score (CSMS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Der p-specific IgG4;Serum Der p-specific IgE;Skin Prick Test (SPT); | — |
Countries
China
Contacts
Public ContactHaiyu Hong
The Fifth Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed