Autism spectrum disorder
Conditions
Interventions
true stimulation group:The active stimulation group received comprehensive rehabilitation therapy and 1Hz rTMS treatment based on this protocol, administered once daily for 20 minutes per session, fiv
sham stimulation group:Comprehensive Rehabilitation Therapy, Treatment Duration time: is 12 Weeks
Sponsors
Children's Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
2 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. All participants met the DSM-5 diagnostic criteria for ASD; 2. Participants were aged 2 to 6 years; 3. Participants were right-handed; 4. Participants had no active intracranial lesions and no history of traumatic brain injury; 5. Guardians voluntarily participated in this study, provided informed consent after receiving comprehensive information, and agreed to adhere to the study protocol.
Exclusion criteria
Exclusion criteria: 1. History of childhood schizophrenia, epileptic seizures, or abnormal electroencephalogram (EEG) findings; 2. Presence of intracranial hypertension or concomitant major organ disease; 3. Previous transcranial magnetic stimulation (TMS) or integrative rehabilitation therapy; 4. Implanted metallic or electronic devices near the magnetic stimulation target area, such as cochlear implants, pulse generators, or medical pumps.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Autism Behavior Checklist(ABC);Childhood Autism Rating Scale( CARS);Repetitive Behavior Scale -Revised(RBS-R);Autism Treatment Evaluation Checklist(ATEC);Regional Homogeneity(ReHo);Amplitude of Low-Frequency Fluctuations(ALFF); | — |
Countries
China
Contacts
Public ContactMin Zhu
Children's Hospital of Nanjing Medical University
Outcome results
None listed