Systemic lupus erythematosus
Conditions
Interventions
Healthy Control Group:None
Sponsors
The First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Meeting the 1997 classification criteria for systemic lupus erythematosus (SLE) recommended by the American College of Rheumatology (ACR) or the 2009 ACR classification criteria for SLE; 2.Aged 18–50 years; 3.Educational level of primary school or above, proficient in Mandarin Chinese with capacity to comprehend scale contents, and capable of completing the questionnaires; 4.Signed informed consent by the patient and their guardian. Control group: 1. Age and gender matched with patients; 2. Voluntarily participate in this study; 3. Age 18-50 years; 4. Elementary school education or above
Exclusion criteria
Exclusion criteria: 1.Diagnosed with schizophrenia, mental retardation, alcohol abuse, alcohol dependence, or other psychoactive substance dependence; 2.History of major organic brain diseases, including trauma, tumor, stroke, infection, contagious disease, epilepsy, or definite neurodegenerative disorders; comorbid with other autoimmune diseases meeting ACR classification criteria for rheumatoid arthritis, systemic sclerosis, Sjögren's syndrome (primary or secondary), other connective tissue diseases, or drug-induced SLE; 3.Patients with severe cardiac, hepatic, renal, or pulmonary insufficiency; 4.Women who are pregnant, lactating, or planning pregnancy; 5.Patients with MRI contraindications, such as implanted vascular stents, pacemakers, metal dentures, hearing aids, etc.; or patients with claustrophobia; 6.Patients with previous clinical conditions potentially causing brain atrophy (stroke, hypertension, diabetes mellitus, drug or alcohol dependence). Control Group: 1. Individuals with a family or personal history of significant somatic diseases; 2. Individuals with a family or personal history of immune system disorders; 3. Individuals with a family or personal history of neuropsychiatric disorders; 4. Individuals with a history of substance abuse, screened by an experienced psychiatrist using the DSM-IV Structured Clinical Interview for Non-Patient Version.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-report scales scores: Symptom Checklist-90, Self-Rating Anxiety Scale, Self-Rating Depression Scale , 36-Item Short Form Health Survey, Fatigue Severity Scale; ;sMRI, fMRI, and DTI data; SLE-related autoantibodies, cytokines, and absolute lymphocyte subset count analysis.;Clinician-administered scale scores : Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale,Montreal Cognitive Assessment;; | — |
Countries
China
Contacts
Public ContactBai Ru
The First Affiliated Hospital of Kunming Medical University
Outcome results
None listed