acute lymphoblastic leukemia
Conditions
Interventions
Experiment Group (Ovarian Tissue Cryopreservation):None
Control Group (Absence of Ovarian Tissue Cryopreservation):None
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
7 Years to 13 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed as a pediatric patient with ALL, according to the diagnostic criteria referenced from the NCCN Guidelines 2025 V2: >=20% blasts and immature lymphocytes were found in bone marrow aspirate and biopsy specimens. If there is a sufficient number of circulating blasts and immature lymphocytes in peripheral blood (>=1x10?/L) and the clinical situation does not permit bone marrow aspiration and biopsy, peripheral blood can be used as a substitute for bone marrow. 2. Aged 7-13 years, female, premenarchal, with requirements for endocrine function and fertility preservation, and in complete remission after receiving prior non-alkylating agent-based chemotherapy. 3. Laboratory examination: AMH =50%.
Exclusion criteria
Exclusion criteria: Patients meeting any of the following criteria will be excluded: 1. Patients with contraindications to laparoscopic surgery. 2. Patients with critical illness or poor prognosis. 3. Patients who have received chemotherapy with high-risk ovarian damaging agents (alkylating agents) or radiotherapy. 4. Patients with severe endocrine, metabolic, or systemic diseases. 5. Other conditions deemed by the investigator as unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Menstrual cycle status (including presence or absence of menstrual cycles, duration of menstruation, menstrual volume, etc.);The AMH level in peripheral blood;Gonadal hormone level;Number of antral follicles; | — |
Secondary
| Measure | Time frame |
|---|---|
| The duration of ovarian function maintenance; | — |
Countries
China
Contacts
Public ContactLi Fei
The First Affiliated Hospital of Nanchang University
Outcome results
None listed