Reduced cerebral blood flow
Conditions
Interventions
the propofol group:Intravenous injection of propofol at 1.5~ 2mg/kg
the remimazolam group:Intravenous injection of remimazolam at 0.2mg/kg
the etomidate group:Intravenous injection of etomidate at 0.3mg/kg
Sponsors
Yantai Yuhuangding Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Elderly patients who are scheduled to undergo gastrointestinal surgeries such as gastrectomy, enterectomy, appendectomy, and rectotomy; 2. Age: 65-85 years old,Weight: 50 to 80 kilograms; 3.The estimated operation time is 2 to 6 hours; 4. Cardiac function grade II to III; 5.ASA classification II and III;
Exclusion criteria
Exclusion criteria: 1. Relative contraindications for general anesthesia: Patients with severe heart and lung diseases; 2. There is a history of syncope and dizziness; 3. Those with a history of mental illness, neurology, drug abuse or addiction; 4. Patients with cerebrovascular or carotid artery diseases; 5. Have taken benzodiazepines intermittently in the past three months; 6. Those who are known to have an allergic constitution or are allergic to the test drug; 7. TCD is unable to detect the blood flow signal of the middle cerebral artery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peak systolic blood flow velocity (Vs);pulsatility index (PI);potency index (RI);mean blood flow velocity (Vm); | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate (HR);mean arterial pressure (MAP); | — |
Countries
China
Contacts
Public ContactMa Jiahai
Yantai Yuhuangding Hospital
Outcome results
None listed