Contrast-Induced Acute Kidney Injury
Conditions
Interventions
Experiment Group:The experimental group, which received the individualized high-volume hydration regimen, had its hydration rate determined based on dynamically measured EDFR levels: when EDFR was les
when EDFR was between 50% and 67%, the rate was 1.5 ml/kg/h
and when EDFR was greater than 67%, the rate was 1 ml/kg/h, maintained until 12 to 24 hours after surgery.
Control Group:The control group, which received the standard hydration regimen, was infused with normal saline at a rate of 1 ml/kg/h 6 to 12 hours before the injection of contrast medium and maintain
Sponsors
Zhongda Hospital Affiliated to Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Volunteer to participate in this trial and sign the informed consent form; 2. Aged >=18 and = 6; 5. Non-invasive cardiac output measurement 6 hours before surgery shows EDFR < 50%; 6. Volunteer to participate in this trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergic to contrast medium or having received contrast medium within 7 days; 2. Patients with existing or suspected acute kidney injury; 3. Pregnant or breastfeeding individuals; 4. Patients who require regular hemodialysis, peritoneal dialysis, other renal replacement therapies, unilateral nephrectomy, or kidney transplantation; 5. Those who have taken aminoglycosides, aristolochic acids, cisplatin, or other nephrotoxic drugs within one week before enrollment; 6. Patients with acute heart failure, severe infectious diseases, connective tissue disease, liver failure, tumors, sudden cardiac death, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Contrast-Induced Acute Kidney Injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Major Adverse Cardiovascular Event;Major Adverse Kidney Event; | — |
Countries
China
Contacts
Public ContactGaoliang Yan
Department of Cardiology, Zhongda Hospital Affiliated to Southeast University
Outcome results
None listed