Severe pneumonia
Conditions
Interventions
Control group:Standard anti-infection treatment
Experimental group:Local application of amikacin for pulmonary lavage combined with standard anti-infection treatment
Sponsors
Panyu Maternal And Child Care Service Centre Of Guangzhou
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years, diagnosed with hospital-acquired/ventilator-associated pneumonia; 2. Presence of segmental pneumonia, non-diffuse lung infection; 3. Sputum/BALF culture confirming drug-resistant G- bacteria (Carbapenem-resistant Acinetobacter baumannii/Pseudomonas aeruginosa/Klebsiella pneumoniae, etc.); 4. APACHE II score 10-25, systemic anti-infective treatment >=72 hours ineffective (fever not reduced, oxygenation worsened, infection indicators not decreased).
Exclusion criteria
Exclusion criteria: 1. Patients under 18 years old or over 75 years old; 2. Diffuse pulmonary fibrosis/pulmonary hemorrhage, bronchopleural fistula, severe airway stenosis; 3. History of chronic neurological insufficiency/baseline creatinine clearance <30ml/min; 4. Pregnancy; 5. Allergy to amikacin; 6. At the end stage of disease, with conditions that may affect study participation or outcome assessment, or severe underlying diseases that make it impossible to complete the follow-up required by the study protocol due to end-stage disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Cure Rate;Microbiological Eradication Rate;Incidence of Local Adverse Events;Incidence of Nephrotoxicity; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-Day All-Cause Mortality;Length of ICU Stay;Weaning Rate from Mechanical Ventilation;Dynamic Changes of Inflammatory Biomarkers;Incidence of Liver Enzyme Abnormalities; | — |
Countries
China
Contacts
Public ContactYang Kaiying
Panyu Maternal And Child Care Service Centre Of Guangzhou
Outcome results
None listed