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Optimization of Multidimensional Visual Rehabilitation Strategies for Patients with Primary Open-Angle Glaucoma Based on the 'Eye-Brain-Vascular' Approach

Optimization of Multidimensional Visual Rehabilitation Strategies for Patients with Primary Open-Angle Glaucoma Based on the 'Eye-Brain-Vascular' Approach

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600120191
Enrollment
Unknown
Registered
2026-03-10
Start date
2026-03-10
Completion date
Unknown
Last updated
2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary open-angle glaucoma

Interventions

Experimental group:All patients received basic treatment and multidimensional visual rehabilitation therapy, with specific details as follows: 1. Basic drugs: Conventional medication, including drugs

Sponsors

Shanghai Tongren Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. One eye has typical glaucomatous optic disc damage and vision loss, while the other eye has vision loss or typical glaucomatous optic disc damage, or both. 2. Intraocular pressure <22mmHg (with or without local treatment). 3. Age 18-80 years. 4. Signed informed consent and willingness to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Any type of glaucoma other than POAG. 2. Severe media opacity that would interfere with the detection of study effects (e.g., cataract or corneal scar). 3. Vision impairment caused by other ophthalmic reasons (such as age-related macular degeneration). 4. Underwent any type of surgery or laser treatment in the past 3 months. 5. Any change in glaucoma medication within the past 3 months, and/or using more than two topical IOP-lowering medications (or any oral medications) at baseline visit. 6. Patients with overall visual impairment due to ptosis or skin cracking of the eyelids. 7. History of brain surgery or neurological disease (stroke, seizure, or epilepsy). 8. Uncontrolled hypertension (>160 mmHg).

Design outcomes

Primary

MeasureTime frame
mean deviation;visual field index;

Secondary

MeasureTime frame
best vision correction;intraocular pressure;vessel density;pattern Visual Evoked Potential;retinal nerve fiber layer;National Eye Institute Visual Function Questionnaire-25;Short Form 36 Health Survey Questionnaire;Pittsburgh sleep quality index;Functional Near-Infrared Spectroscopy Detection;

Countries

China

Contacts

Public ContactChen Qianru

Shanghai Tongren Hospital

cqr4362@shtrhospital.com+86 21 5203 9999

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 20, 2026