Obesity
Conditions
Interventions
Dezocine group:30 minutes before the surgical incision, the anesthesiologist administered the test drug, dezocine injection, intravenously at a rate of 0.1mg/kg.
Saline Group:30 minutes before the surgical incision, the anesthesiologist slowly injected an equal volume of 0.9% normal saline intravenously along with the test drug.
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 65 years old; 2. ASA classification: Grade I-II; 3. Patients scheduled to undergo elective, primary, single-segment or double-segment anterior cervical discectomy and fusion surgery; 4. Preoperative swallowing function is normal, and there are no obvious abnormalities in the preoperative swallowing function as screened by the EAT-10 questionnaire (EAT-10 <= 3). 5. Within 24 hours before the surgery, the patient has not used opioid or non-steroidal analgesics or other painkillers; 6. The patient voluntarily participates and can cooperate to complete the postoperative assessment.
Exclusion criteria
Exclusion criteria: 1. History of allergy to dezocine, opioids, or other anesthetic agents used in the study; 2. Pre-existing dysphagia or odynophagia due to any cause (neurological, structural, or functional) confirmed by history or preoperative assessment; 3. History of previous cervical spine surgery; 4. Patients with anticipated difficult airway, or those planned for postoperative retention of endotracheal tube or delayed extubation; 5. History of alcohol or drug abuse: e.g., preoperative opioid dependence, use of >100 mg morphine equivalent per week preoperatively, or use of local anesthetics for pain control for >3 months; 6. Contraindications to dezocine: history of peptic ulcer, platelet dysfunction, coagulation disorders, or current anticoagulant therapy; 7. Patients with severe organ dysfunction; 8. Pregnant or lactating women; 9. Patients currently participating in other clinical drug trials prior to this study; 10. Patients who refuse to participate or are unable to complete follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative swallowing pain visual analog scale (VAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Swallowing function grading;Rescue analgesic medication use postoperatively;Intraoperative total anesthesia drug dosage;Postoperative recovery indicator (time to first intake);Postoperative hospital stay duration; | — |
Countries
China
Contacts
Public ContactDeng Bin
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed