Abdominal aortic aneurysm
Conditions
Interventions
Abdominal aortic aneurysm group:None
Sponsors
First Medical Center, PLA General Hospital
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 40 years, regardless of gender. 2. Diagnosed with abdominal aortic aneurysm by imaging and evaluated by a vascular surgeon as scheduled to undergo EVAR (including those with planned surgery or scheduled for short-term surgery). 3. Meeting at least one surgical indication: maximum diameter >= 50 mm, or documented rapid expansion (e.g., >10 mm/year as determined by the center's criteria). 4. Able to understand and sign a written informed consent form. 5. Expected to be compliant and successfully complete follow-up (for at least 12 months).
Exclusion criteria
Exclusion criteria: 1. Patients who have previously undergone abdominal aortic repair/stenting. 2. Patients with acute symptomatic ruptured abdominal aortic aneurysm. 3. Patients with genetic or inflammatory aortic diseases (e.g., Marfan syndrome, Loeys-Dietz syndrome, giant cell arteritis, Takayasu arteritis, infectious aneurysms, etc.). 4. Patients with abdominal aortic aneurysm not meeting surgical indications. 5. Patients with severe renal impairment (eGFR < 30 ml/min) and those at high risk for contrast-induced complications. 6. Women who are pregnant or lactating, or subjects planning a pregnancy. 7. Subjects with a known severe allergy to the study tracer or its formulation, or those who cannot undergo nuclear medicine examinations. 8. Subjects with a life expectancy of less than 12 months. 9. Subjects unable to comply with the PET/CT scan requirements (e.g., due to severe mental illness, inability to cooperate). 10. Subjects concurrently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of new-onset or persistent endoleak within 12 months post-surgery;Postoperative changes in aneurysm sac diameter (sac regression/stability/expansion);Incidence of required re-intervention within 12 months post-surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stent-graft related structural complications after EVAR;Clinical prognostic events;Correlation between preoperative FAPI uptake parameters and postoperative imaging, biological, and clinical events; | — |
Countries
China
Contacts
Public ContactBi Xiao
First Medical Center, PLA General Hospital
Outcome results
None listed