Digestive System Diseases
Conditions
Interventions
Control group (Ciprofol and Remimazolam only):For the control group patients, they were first given an equal amount of normal saline, then 0.08 - 0.1 mg/kg remifentanil was administered, followed by 0
Experimental group (cyclopropofol, remimazolam and alfentanil):All patients in the experimental group were first given a 3 µg/kg intravenous injection of alfentanil, then 0.08 - 0.1 mg/kg remifentanil
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: A total of 504 patients who underwent painless gastroscopy or painless gastroscopy combined with painless colonoscopy at the Gastrointestinal Endoscopy Center of the Second Xiangya Hospital, Central South University, from March 2026 to March 2027 were enrolled. The patients were classified as ASA grades I to III, aged between 18 and 64 years, with a MET score>= 3, and a BMI between 18 kg/m^2 and < 28 kg/m^2.
Exclusion criteria
Exclusion criteria: Exclusion criteria included: patients with ASA grade IV or above; severe tooth looseness; patients with very severe obstructive ventilatory dysfunction; those with anemia or thrombocytopenia; patients with pre-anesthesia pulse oxygen saturation (SpO2) < 94%; patients with severe liver or kidney dysfunction; pregnant or lactating patients; those with allergies or contraindications to benzodiazepines, ciprofol, or alfentanil; patients who had participated in other drug clinical trials within the previous 3 months; or any other conditions the investigators deemed unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough; | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare the effects of the two groups of sedation protocols on the safety of respiration and circulation, including the incidence and handling requirements of sedation-related adverse events such as hypoxemia, respiratory depression, and hypotension, and evaluate their clinical applicability.;Compare the sedation quality indicators of the two groups of schemes, including the incidence of body movement and the ratio of additional sedation/medication for rescue.; | — |
Countries
China
Contacts
Public ContactRuyi Luo
The Second Xiangya Hospital of Central South University
Outcome results
None listed