Heart valve disease, Congenital heart disease
Conditions
Interventions
Conventional CPB control group:Conventional extracorporeal circulation device, conventional pre charge, no intervention
Improved mini experimental group:Improved Mini Extracorporeal Circulation
Sponsors
The Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Male or female aged 18-70 years with heart disease requiring cardiac surgery with cardiopulmonary bypass 2. Weight 35 ~ 50kg 3. The patient has a history of heart disease with corresponding clinical manifestations (symptoms and signs);
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. According to KDIGO criteria G3 and lower categories of chronic kidney disease (with at least one of the following manifestations>3 months: glomerular filtration rate <= 60 ml/min/1.73 square meters, history of kidney transplantation); 3. Pregnant women; 4. Second or multiple surgeries; 5. Large vessel surgery; 6. Full thoracoscopy and thoracoscopic assisted cardiac surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Red blood cell concentration;HsCRP;Inflammatory factor IL-10;Pro-inflammatory factor IL-6;Inflammatory factor TNF-a;Pro-inflammatory factor IL-8; Free hemoglobin; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU Length of Stay;Cardiac Troponin I;Creatine kinase isoenzymes;Cardiac Troponin T;Incidence of Organ Failure;Fresh frozen plasma transfusion volume;Platelet count;Ultrafiltration Usage;Duration of mechanical ventilation;Blood loss;Red blood cell transfusion volume and infusion rate;Thoracic drainage volume;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactSong Chengyi
The Affiliated Hospital of Southwest Medical University
Outcome results
None listed