Depression
Conditions
Interventions
Normal control group:Non
Depression without anhedonia group:None
Depression with anhedonia group:None
Sponsors
Hangzhou Seventh People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Patient group: 1.Age: 18-45 years old (inclusive); 2.Ethnicity: Han Chinese; 3.Handedness: Right-handed; 4.Episode: First-episode patients; 5.Education & functioning: Primary school graduate or above, with premorbidly normal social functioning; 6.Diagnosis: Meeting diagnostic criteria for major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 7.Medication history: No prior use of any antipsychotics, antidepressants, benzodiazepines, or other central nervous system (CNS)-acting medications or antidepressant monotherapy for 5. Normal control group: 1.Age: 18-45 years old (inclusive); 2.Ethnicity: Han Chinese; 3.Handedness: Right-handed; 4.Education: Primary school graduate or above; 5.Functioning: Intact social functioning; 6.Consent: Voluntary participation and provision of informed consent.
Exclusion criteria
Exclusion criteria: Patient group: 1.History of organic brain disease, neurological disorders, or severe endocrine/metabolic diseases; 2.History of traumatic brain injury with associated coma; 3.Prior diagnosis of other psychiatric disorders according to DSM-5 criteria; 4.Non-cooperative or unable to effectively complete study examinations; 5.Presence of fixed metal dental prostheses, cardiac pacemakers, or other metal implants; 6.Pregnant or lactating women. Normal control group: 1.History of any psychiatric disorder diagnosed by DSM-5 criteria; 2.History of traumatic brain injury with associated coma; 3.Positive family history of mental illness (first- and second-degree relatives within three generations); 4.History of psychotropic medication use (e.g., antipsychotics, antidepressants); 5.Presence of fixed metal dental prostheses, cardiac pacemakers, or other metal implants; 6.Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anhedonia scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral metabolite indicators;General and clinical information;Anxiety scores;Depressive symptom scores;Brain functional connectivity level; | — |
Countries
China
Contacts
Public ContactSugai Liang
Hangzhou Seventh People's Hospital
Outcome results
None listed