Obesity
Conditions
Interventions
Combined intervention group:None
Exercise intervention group:None
Diet intervention group:None
Pharmacological intervention group:None
Sponsors
Fuzhou University Affiliated Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18–65 years; 2.BMI >= 28 kg/m^2; 3.Planned to receive weight-loss interventions and standardized clinical weight-management at our hospital; 4.No participation in any other weight-loss interventions within the past 3 months (e.g., bariatric surgery, weight-loss medications, extreme dieting, etc.); 5.Able to complete follow-up visits as required by the study and willing to undergo questionnaire assessments and provide biological samples including blood, urine, and stool; 6.Voluntarily signs the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.Presence of severe cardiac, hepatic, or renal insufficiency, or active malignancy; 3.Diagnosed inflammatory bowel disease, short bowel syndrome, or other severe gastrointestinal conditions that may markedly affect nutrient absorption or gut microbiot; 4.Use of medications within the past 3 months that may influence the microbiome or metabolic status (e.g., antibiotics, probiotic preparations, high-dose glucocorticoids, immunosuppressants); 5.History of bariatric surgery; 6.Recent acute illness, major surgery, or other events that may influence body weight or metabolic status; 7.Presence of psychiatric or cognitive disorders that prevent adequate cooperation with follow-up or completion of study procedures;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| Risk of Weight Regain;Dynamic Changes in Multi-omics Profiles;Improvements in Glucose–Lipid Metabolism and Insulin Sensitivity;Changes in Inflammatory Biomarkers; | — |
Countries
China
Contacts
Public ContactWen Junping
Fuzhou University Affiliated Provincial Hospital
Outcome results
None listed