HIV infection
Conditions
Interventions
Aspirin combined with ART Group:Oral aspirin (100 mg) administered daily in the morning, on the background of continuous antiretroviral therapy (ART), for a duration of 24 weeks.
Standard ART Group:Continuous antiretroviral therapy (ART) alone, without aspirin administration, for a duration of 24 weeks
Sponsors
Beijing Ditan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. HIV-1 infected patients with suboptimal immune reconstitution after receiving effective antiretroviral therapy (ART) for more than 4 years. 2. Confirmed HIV-1 infection, defined as positive HIV-1 antibody test by ELISA and confirmed by Western blot. 3. Aged 18 to 65 years (inclusive), regardless of gender. 4. Received initial treatment at this hospital, voluntarily participated and signed the informed consent form; 5. Good self-care ability and ability to comply with the study protocol.
Exclusion criteria
Exclusion criteria: 1. Severe hepatic or renal impairment (e.g., hepatitis, renal failure). 2. Bleeding diathesis, active peptic ulcer, or a history of peptic ulcer disease. 3. Concomitant use of other medications that affect the immune system or lipid levels (e.g., immunosuppressants). 4. Pregnant or lactating women. 5. History of allergy or hypersensitivity to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). 6. Recent severe complications or other concurrent diseases (e.g., cardiovascular disease). 7. Thrombocytopenia. 8. Current participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD4/CD8 ratio;HIV-1 Viral Load;CD4 T lymphocytes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory indicators (blood routine, four items of coagulation function, blood lipids, liver function, kidney function);Immunological Parameters; | — |
Countries
China
Contacts
Public ContactYaxian Kong
Beijing Ditan Hospital, Capital Medical University
Outcome results
None listed