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LAG-3-Mediated Dynamic Regulatory Mechanisms and Targeted Therapy Study in Sepsis-Induced Immune Dysregulation

LAG-3-Mediated Dynamic Regulatory Mechanisms and Targeted Therapy Study in Sepsis-Induced Immune Dysregulation

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600120136
Enrollment
Unknown
Registered
2026-03-10
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

LAG-3 high-expression group:None
LAG-3 low-expression group:None

Sponsors

Fuzhou University Affiliated Provincial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >= 18 years; 2.Within 24 hours after gastrointestinal perforation surgery and meeting the Sepsis-3 diagnostic criteria (infection + SOFA score>= 2); 3.Signed informed consent form;

Exclusion criteria

Exclusion criteria: 1.Pregnancy; 2.Active malignancy; 3.Immunodeficiency disorders such as HIV infection, long-term use of immunosuppressive agents (e.g., glucocorticoids at a dose equivalent to >10 mg/day of prednisone); 4.Expected survival time < 24 hours or withdrawal from active treatment;

Design outcomes

Primary

MeasureTime frame
28-day all-cause mortality;—

Secondary

MeasureTime frame
ICU length of stay and total hospital length of stay;SOFA score, APACHE II score;the incidence of secondary infections within 28 days;—

Countries

China

Contacts

Public ContactXiuling Shang

Fuzhou University Affiliated Provincial Hospital

zksxling@163.com+86 591 88217010

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 20, 2026