depression
Conditions
Interventions
iTBS treatment group:intermittent theta burst stimulation + Drug
Control group:Pseudo-stimulation + Drug
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
10 Years to 19 Years
Inclusion criteria
Inclusion criteria: 1. Age 10 to 19 years, of any gender. 2. Meets the DSM-5 diagnostic criteria for major depressive disorder and is currently in an episode. 3. First Beck Depression Inventory-II (BDI-II) total score >= 20 points. 4. Overall health is determined to be good based on medical history. 5. The patient voluntarily participates and has obtained consent from a guardian to participate in this study, signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Meets DSM-5 diagnostic criteria for psychiatric disorders such as psychotic disorders, manic episodes, autism spectrum disorder, intellectual disability, tic disorders, substance abuse, etc. 2. Presence of severe organic brain disease. 3. History of febrile seizures or epilepsy. 4. Clear suicidal thoughts, attempts, or behaviors within the past month. 5. Presence of metal implants in the head or skull, pacemaker, or cochlear implant. 6. Previous rTMS treatment with no response to an adequate course (i.e., at least 8 sessions of electroconvulsive therapy). 7. Positive urine toxicology screen, positive urine pregnancy test (for females only).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BDI-II score; | — |
Secondary
| Measure | Time frame |
|---|---|
| remission rate;Effective Rate;Number of adverse events and incidence rate; | — |
Countries
China
Contacts
Public ContactYi Huang
West China Hospital of Sichuan University
Outcome results
None listed