Hemoperfusion After Renal Injury
Conditions
Interventions
2-hour Hemoperfusion Group:Prolonging the Duration of Hemoperfusion Therapy and Adjusting the Treatment Flow Rate of Hemoperfusion Combined with Hemodialysis
4-hour Hemoperfusion Group:Prolonging the Duration of Hemoperfusion Therapy and Adjusting the Treatment Flow Rate of Hemoperfusion Combined with Hemodialysis
Sponsors
Lianyungang First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged >= 18 years, regardless of gender; 2.Undergoing maintenance hemodialysis for more than 3 months; 3.Receiving regular hemodialysis treatment, 3 times per week and 4 hours per session; 4.No restrictions on vascular access; 5.Voluntarily participating in the trial and signing a written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Subjects with a known history of allergy, contraindications, or intolerance to the materials of dialyzers or hemoperfusion cartridges; 2.Subjects with a platelet count < 60×10^9/L; 3.Subjects with a blood flow rate < 200 ml/min; 4.Subjects with other coagulation disorders, severe bleeding tendency, or active bleeding; 5.Subjects with hypotension or severe cardiopulmonary insufficiency; 6.Subjects currently or recently (within 30 days) participating in other drug research projects; 7.Subjects complicated with acute and critical illnesses such as acute infections, severe heart, lung, liver, or nervous system diseases, as well as malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Toxin Clearance Rate and Clinical Safety Before and After Perfusion;Solute clearance rate (ß2-MG, leptin, light chain protein, end-stage glycosylation products, blood phosphorus); | — |
Secondary
| Measure | Time frame |
|---|---|
| Optimization Effect of Clinical Nursing Care During Hemodialysis Combined With Hemoperfusion in This Study;Renal function (KT/V);Nursing workload;The amount of normal saline returned to the blood; | — |
Countries
China
Contacts
Public ContactZhang Liyuan
Lianyungang First People's Hospital
Outcome results
None listed