Gastrointestinal perforation (sepsis)
Conditions
Interventions
High-dose group (0.75 ug/kg/h):Dexmedetomidine hydrochloride is infused at a rate of 0.75 micrograms per kilogram per hour.
The medium-dose group:Dexmedetomidine hydrochloride is infused at a rate of 0.5 micrograms per kilogram per hour.
Low-dose group:Dexmedetomidine hydrochloride is infused at a rate of 0.25 micrograms per kilogram per hour.
Control group:Infusion of normal saline was used as the control group
Sponsors
Xuzhou Medical University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Patients who underwent emergency surgery for gastric perforation; 3. Patients with infection and Sequential Organ Failure Assessment (SOFA) score >= 2 points; 4. ASA classification I-III; 5. Those who agree to participate in the trial and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Second or third degree atrioventricular conduction block or severe bradycardia requiring intervention; 2. Those allergic to dexmedetomidine or propofol; 3. Severe myocardial infarction or malignant arrhythmia; 4. Those expected to stop mechanical ventilation soon.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin-6 (IL-6); | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin-1ß (IL-1ß), Tumor Necrosis Factor-a (TNF-a);C-reactive protein (CRP) and procalcitonin (PCT);Oxygenation Index (PaO?/FiO?), blood lactate;Heart rate, mean arterial pressure;Dosage of vasoactive drugs and propofol ;Mechanical ventilation duration, ICU hospitalization time;Postoperative mortality rate at 30 days;Occurrence of Adverse Events; | — |
Countries
China
Contacts
Public ContactLin Bu
Xuzhou Medical University Affiliated Hospital
Outcome results
None listed