pancreatic cancer
Conditions
Interventions
Pancreatic cancer patients:None
Sponsors
Jiangsu Province Hospital ( The First Affiliated Hospital of Nanjing Medical University)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Age between 18 and 65 years old, with no gender restrictions; 2. Diagnosed with pancreatic cancer through histopathological examination. There is clear imaging evidence (such as CT, MRI, ultrasound, etc.) to support the diagnosis of pancreatic cancer; 3. Patients who have not received anti-tumor treatments such as radiotherapy, chemotherapy, targeted therapy, or immunotherapy before the surgery; 4. Able to provide tumor tissue and adjacent tissue samples for research analysis. Sufficient tumor tissue and adjacent tissue can be obtained during the surgery for subsequent analysis; 5. Patients agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Patients with non-pancreatic cancer (such as gastric cancer, liver cancer, bile duct cancer, etc.) or suspected benign tumors of other types in the pancreas (such as pancreatic cysts); 2. Patients whose tumor tissue samples cannot meet the requirements for experimental detection due to excessive necrotic area or insufficient sampling; 3. Patients who have received anti-tumor treatments such as radiotherapy, chemotherapy, targeted therapy, or immunotherapy before the surgery; 4. Patients with severe systemic diseases (such as severe heart and lung diseases, liver and kidney failure, immune deficiency, etc.), which may affect the treatment or survival status of the patients; 5. Patients with severe infections or in an immunosuppressed state (such as HIV-infected individuals, users of immunosuppressive drugs, etc.); 6. Patients with a previous history of other malignant tumors, and the current tumor may affect the assessment of pancreatic cancer; 7. Patients who cannot cooperate with the study or provide informed consent. Tumor tissue and adjacent tissue samples for the study analysis. During the surgery, sufficient tumor tissue and adjacent tissue can be obtained for subsequent analysis; 5. Patients agree to participate in this study and sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the levels of NETs; | — |
Secondary
| Measure | Time frame |
|---|---|
| the expression levels of NLRP3 proteins;the levels of IL-1ß proteins;the levels of IL-18 proteins; | — |
Countries
China
Contacts
Public ContactLinjia Zhu
Jiangsu Province Hospital ( The First Affiliated Hospital of Nanjing Medical University)
Outcome results
None listed