Meibomian Gland Dysfunction (MGD) and associated Dry Eye Disease.
Conditions
Interventions
Dry Eye Syndrome Observation Group:None
Sponsors
Fuzhou University Affiliated Provincial Hospital
Eligibility
Sex/Gender
All
Age
4 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged between 4 and 80 years old. 2. Meets the clinical diagnostic criteria for meibomian gland dysfunction (MGD). 3. The subjects (or their legal guardians) are able to cooperate in completing the ophthalmic image collection and subsequent follow-up. 4. Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who have previously received targeted treatment for dry eye or meibomian gland-related conditions. 2. Those with other severe ocular surface or eye diseases, such as blepharitis, entropion, glaucoma, etc. 3. Those with severe systemic diseases, such as severe liver or kidney dysfunction or malignant tumors. 4. Those with a history of using drugs that may affect the stability of the tear film (such as isotretinoin, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy of AI classification model;Sensitivity of AI classification model;Cohen’s Kappa between AI and expert classification;Area Under the Curve (AUC) of AI classification model;Specificity of AI classification model; | — |
Secondary
| Measure | Time frame |
|---|---|
| Concordance of AI recommendations with clinicians;Cross-center robustness;F1-score of AI model;SHAP feature contribution;Brier score;Intraclass Correlation Coefficient (ICC) of radiomic features;Accuracy of Grad-CAM lesion localization; | — |
Countries
China
Contacts
Public ContactLi Li
Fuzhou University Affiliated Provincial Hospital
Outcome results
None listed