Postoperative delirium
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 65 to 90 years; 2. Patients scheduled for elective urological, orthopedic, general surgical, or thoracic surgical procedures; 3. Moderate-to-major surgeries with an anticipated duration >=1 hour; 4. Expected postoperative hospital stay >=72 hours; 5. American Society of Anesthesiologists (ASA) Physical Status Classification of II–III; 6. Patients with normal preoperative cognitive function (Montreal Cognitive Assessment, Version 8.1 score >=22); 7. Patients or their legally authorized representatives provided informed consent and agreed to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Patients with a documented history of psychiatric or neurological disorders, such as depression, severe central nervous system depression, schizophrenia, epilepsy, Parkinson's disease, or Alzheimer's disease; 2. Individuals unable to undergo cognitive testing due to hearing or visual impairments; 3. Preoperative use of psychotropic medications or opioids; 4. Presence of preoperative conditions affecting normal communication, including delirium, coma, or dementia; 5. Patients with severe cardiac disease (NYHA Class III or IV), hepatic insufficiency (Child-Pugh Class C), severe renal dysfunction (estimated glomerular filtration rate 3 months) use of zinc supplements prior to surgery; 8. Current participation in other clinical trials; 9. Planned secondary surgical procedures within 7 days postoperatively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of delirium;Severity of postoperative delirium;Perioperative electroencephalography and related EEG parameters;Postoperative recovery quality QoR15;Resting and exercise NRS score;Incidence of postoperative nausea and vomiting (PONV);30-day all-cause mortality rate;Incidence of complications after surgery; | — |
Countries
China
Contacts
Public ContactChen Lijian
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed