Association between preoperative thigh muscle mass and outcomes after TKA in patients with hemophilic knee arthritis

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600120082

Enrollment

Unknown

Registered

2026-03-09

Start date

2026-03-20

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemophilic arthritis

Interventions

Hemophilic Knee Osteoarthritis Group (KHA Group):None

Knee Osteoarthritis Group (KOA Group):None

Eligibility

Sex/Gender

Male

Age

22 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. KHA Group Inclusion Criteria (1) Age 18-65 years; meet "Chinese Expert Consensus on Diagnosis and Treatment of Hemophilia (2021 Edition)"; confirmed hemophilia A/B diagnosis; unilateral or bilateral knee involvement (confirmed by physical exam and knee X-ray showing arthritis features, Arnold-Hilgartner score grade IV or higher); (2) Knee disease duration >=1 year; (3) No acute knee hemorrhage in the past 2 weeks; (4) Undergoing unilateral total knee arthroplasty (TKA); (5) Capable of independently completing CT examination and lower limb functional assessment. 2. KOA Group Inclusion Criteria (1) 1:1 individual matching with KHA group (matching criteria: same gender, BMI +/-2.0 kg/m^2); (2) Meet American College of Rheumatology (ACR) osteoarthritis diagnostic criteria; knee X-ray Kellgren-Lawrence (K-L) grade 3-4; (3) Knee disease duration >=1 year; (4) No acute knee pain episode in the past 2 weeks (VAS pain score <=5); (5) Capable of independently completing imaging and functional assessment.

Exclusion criteria

Exclusion criteria: 1. History of previous surgery on the same-side knee; 2. Coexisting neuromuscular diseases, spinal cord injury, or cerebral infarction; 3. Coexisting severe liver or kidney dysfunction, malignant tumors, or heart failure; 4. Inability to complete follow-up assessments.

Design outcomes

Primary

Measure	Time frame
Skeletal muscle volume (MV);Skeletal muscle quality (SMF);Intermuscular adipose tissue volume (IMAT);Subcutaneous adipose tissue volume (SAT);Knee Society Score (KSS);Short Form-12 Health Survey (SF-12) score;Harris Hip Joint Score (HJHS);Active range of motion (ROM) of the knee joint;	—

Countries

China

Contacts

Public ContactFeng Rui

The Third Affiliated Hospital of Guangzhou University of Chinese Medicine

19313015947@163.com+86 755 28282222

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 20, 2026