glaucoma
Conditions
Interventions
healthy control group:none
Sponsors
The Third Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Glaucoma group 1. Diagnosis of glaucoma All participants in the glaucoma group must have a confirmed diagnosis of glaucoma based on the following criteria: 1) Optic nerve head assessment:The optic nerve head demonstrates typical glaucomatous changes, such as neuroretinal rim thinning/notching and peripapillary retinal nerve fiber layer (RNFL) thinning. 2) Optical coherence tomography (OCT): Thinning of the retinal nerve fiber layer is present. 3) Visual field testing: A glaucomatous visual field defect is confirmed, defined as at least three test points with sensitivity depressed at P < 0.05, with at least one point at P < 0.01 on the 24-2 test pattern, or a positive result on the Glaucoma Hemifield Test. 2. Visual function requirement All glaucoma patients must have a best-corrected visual acuity (BCVA) of = 0.3 in the study eye. 3. Age requirement Participants must be between 18 and 80 years of age. 4. Severity of visual field loss On the 24-2 Humphrey visual field test, the mean deviation (MD) must not be worse than -30 dB, indicating that visual field loss is not extremely advanced. 5. Intraocular pressure must be stable under treatment. 6. Participants must be able to understand and sign the written informed consent form. 7. Participants must be able to cooperate with steady-state visual evoked potential (SSVEP) testing. Healthy control group 1. Participants aged 18–80 years, with no restriction on sex. 2. No history of glaucoma or other ocular diseases. 3. Normal intraocular pressure, normal optic disc appearance, and normal visual field test results. 4. Best-corrected visual acuity = 0.3. 5. Ability to understand and sign the written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of other ocular diseases that may affect visual function, such as visually significant cataract, macular disorders, or other retinal diseases. 2. Best-corrected visual acuity that does not meet the predefined study requirements. 3. Cognitive impairment or any other condition that precludes reliable completion of the examinations. 4. Presence of severe systemic or neurological diseases, including but not limited to epilepsy, stroke, severe hypertension, or diabetic retinopathy. 5. Current use of medications that may affect visual function or electroencephalographic activity. 6. Occurrence of uncorrectable artifacts during SSVEP recording. 7. Pregnancy or lactation. 8. Any other condition considered by the investigators to render the participant unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SSVEP parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Best Corrected Visual Acuity;IOP;Fundus condition;Eye Signs;Optic disc and retinal nerve fiber layer thickness;Field of view; | — |
Countries
China
Contacts
Public ContactWang Dajiang
The Third Medical Center of Chinese PLA General Hospital
Outcome results
None listed