Epilepsy
Conditions
Interventions
Sponsors
Sanbo Brain Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 55 years old, gender not restricted. 2. 2 patients diagnosed with epilepsy by epilepsy specialists, meeting the diagnostic criteria of the International League Against Epilepsy (ILAE) in 2014 and the ILAE epilepsy classification criteria in 2017. 3. Possess diagnostic supporting evidence: clear seizure history records, long-term video electroencephalogram (VEEG) showing epileptiform discharges, and complete results of cranial high-resolution MRI examination. 4. Meet any of the following disease types: Idiopathic generalized epilepsy: meeting the diagnosis of idiopathic generalized epilepsy in the ILAE (2017 edition) epilepsy classification criteria, clinical seizure types include generalized tonic-clonic seizures, absence seizures or myoclonic seizures, EEG shows typical bilateral symmetrical synchronous generalized spike-wave or polyspike-wave discharges, MRI shows no obvious structural abnormalities, onset of seizures is in adolescence or childhood, excluding secondary epilepsy caused by acquired or structural causes; Medial temporal lobe epilepsy: determined that the seizure originates from the medial temporal lobe through comprehensive assessment of clinical seizure characteristics, electroencephalogram (EEG) monitoring, and MRI; Focal cortical dysplasia: MRI examination indicates the imaging features of focal cortical dysplasia, including cortical thickening, blurred gray-white matter junction, abnormal T2/FLAIR signals, etc., clinical seizure characteristics and electroencephalogram monitoring (EEG/SEEG) suggest that the seizure origin is consistent with the imaging lesion; MRI-negative focal epilepsy: clinical seizure characteristics and video electroencephalogram monitoring results suggest that the epileptic focus originates in the focal area, using high-resolution MRI (>= 1.5 T) scanning did not show structural lesions (i.e., MRI-negative).
Exclusion criteria
Exclusion criteria: 1. Patients who cannot be followed up; 2. Those with a history of other major neurological and/or mental disorders; those with intellectual disability, previously diagnosed with dementia or neurodegenerative diseases; 3. Those with other structural abnormalities besides medial temporal lobe sclerosis and cortical dysplasia; 4. Those who have undergone epilepsy surgery (resection or nerve stimulation) in the past; 5. Those with severe underlying diseases: severe cardiovascular and cerebrovascular diseases (acute myocardial infarction, NYHA class ?-? grade heart failure, uncontrolled hypertension (systolic/diastolic pressure >= 160/100 mmHg) or hypotension (systolic pressure < 100 mmHg)), severe liver and kidney dysfunction (Child-Pugh B grade or above, estimated glomerular filtration rate eGFR < 60 ml/min/1.73m^2), malignant tumors (during treatment or in advanced stage, expected survival period < 6 months), active infections (pneumonia, sepsis); 6. Patients who are unwilling to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ß-amyloid protein 1-40;ß-amyloid protein 1-42;Phosphorylated Tau protein 181;Phosphorylated Tau protein at position 217;Neurofilament light chain;Glial Fibrillary Acidic Protein;Microtubule-binding domain tau 243;Non-phosphorylated Tau 217;Phosphorylated Tau 205;Phosphorylated Tau 231;a-synuclein;a-synuclein oligomer;Ubiquitin carboxyl-terminal hydrolase L1;Mini-Mental State Examination score;Montreal Cognitive Assessment score;Wechsler Adult Intelligence Scale-Fourth Edition score;Wechsler Memory Scale-Fourth Edition score;Liverpool Seizure Severity Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| APOE genotype; | — |
Countries
China
Contacts
Public ContactMengyang Wang
Sanbo Brain Hospital, Capital Medical University
Outcome results
None listed