Stroke
Conditions
Interventions
Group of patients with hemiplegia:Non-invasive BCI based on MI combined with hand exoskeleton training
Sponsors
The First Affiliated Hospital of Naval Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18 to 80 years old; 2. Between 1 and 6 months after the first ischemic stroke; 3. Passing the BCI blind screening; 4. Fugl-Meyer upper extremity assessment (FMA-UE) between 20 and 50 points; 5. Right or left upper limb dysfunction; 6. No excessive spasticity, modified Ashworth scale <=3 points 7. Normal cognitive function, able to understand and cooperate with instructions, without other neurological diseases that would affect training; No history of epilepsy and intracranial metal implantation, and TMS screening to ensure safety and access integrity
Exclusion criteria
Exclusion criteria: 1. Primary intracerebral hematoma, subarachnoid hemorrhage, or bilateral hemispheric or bilateral brainstem ischemic stroke 2. Taking medications that may interfere with EEG during the study, including but not limited to diphenhydramine, methylphenidate, caffeine, chlorpromazine, amitriptyline, and dextromethorphan; 3. Other concomitant neuromuscular diseases affecting upper limb motor function; 4.Other neurological diseases that affect the participant's ability to participate in the study; 5.Moderate to severe Cognitive impairment, defined as Montreal Cognitive Assessment (MOCA) score <18/30; 6.Uncontrolled depression or other neuropsychiatric disorders that the subject had taken medication before or after the stroke; 7.The presence of any MRI/EEG risk factors, including but not limited to electrical, magnetic, or mechanically activated metallic or non-metallic implants, including pacemakers or intracerebral clips; A history of metal injury to a non-fixed metal component of any part of the body, including the eye; Pregnancy; A history of epilepsy or seizures after stroke; Patients with lesions on the scalp, bone defect or hemicraniectomy at the predetermined electrode placement site; 8.Patients who have received botulinum toxin injection in the affected upper limb within the past 3 months; 9.Simultaneously participating in another stroke recovery investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electroencephalogram (EEG) data;MEP induced by TMS;Surface electromyography (sEMG); | — |
Countries
China
Contacts
Public ContactFanfu Fang
The First Affiliated Hospital of Naval Medical University
Outcome results
None listed