Degenerative diseases of the lumbar spine
Conditions
Interventions
Control group:Intravenous dexamethasone 10 mg administered at 6 hours and 24 hours post-operatively
Experimental Group One:Intravenous dexamethasone 10mg administered at 6 and 24 hours post-operatively, followed by brief chewing of chewing gum for 10-15 minutes.
Experimental Group Two:Intravenous dexamethasone 10mg administered at 6 and 24 hours post-operatively, followed by prolonged chewing of chewing gum for 25-30 minutes.
Sponsors
West China Tianfu Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients requiring lumbar TLIF surgery due to massive disc herniation, recurrent disc herniation, spondylodesis formation, symptomatic lumbar spondylolisthesis, etc.; 2.Patients aged >=18 years and =2 (those at moderate-to-high risk for PONV); 4.Patients consent to participate in this study and sign the relevant informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with allergies or contraindications to any antiemetic medication required for this study; 2.Use of any study-related antiemetic medication within 8 hours of anaesthetic induction; 3.Patients transferred to the ICU for post-operative care; 4.Patients with contraindications to chewing gum (e.g. those with full/upper dentures, impaired pharyngeal or oesophageal function).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rehabilitation Quality Score(QoR-15 score);Dose of rescue antiemetic medication administered at 24 and 48 hours post-surgery;Length of hospital stay;Time of first spontaneous flatus and bowel movement following surgery;Restoration of bowel sounds;Postoperative complications; | — |
Countries
China
Contacts
Public ContactLiu Li
Sichuan University West China Tianfu Hospital
Outcome results
None listed