Postoperative delirium and cognitive dysfunction
Conditions
Interventions
TXA group:Intravenous infusion of tranexamic acid.
control group:Intravenous infusion of 0.9%NS
Sponsors
Department of Anesthesiology Anhui No.2 Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 105 Years
Inclusion criteria
Inclusion criteria: 1.Elderly patients with fractures diagnosed by imaging (X-ray or CT) and scheduled for surgery. 2.Patients with American Society of Anesthesiologists (ASA) physical status class I-III.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of psychiatric disorders or long-term use of psychotropic medications (e.g., dementia, schizophrenia), chronic analgesic use, or alcohol abuse; 2. Pre-existing delirium; 3. Known allergy to tranexamic acid or any of its components; 4. Patients with hearing or visual impairment, or recent active thrombotic events such as stroke; 5. Patients with severe infection or communication difficulties preventing completion of cognitive function testing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fracture subtype;Duration of delirium;Length of hospital stay;Severity of pain score within 3 days after surgery;30-day all-cause mortality;Serum S100 calcium-binding protein ß;Neuron-specific enolase;C-reactive protein; | — |
Countries
China
Contacts
Public ContactXu Feng
Department of Anesthesiology The NO.2 People's Hospital of Anhui Province
Outcome results
None listed