Cataract
Conditions
Interventions
Patients aged 50 to 85 years who are scheduled to undergo binocular cataract phacoemulsification combined with intraocular lens implantation (grouping: SIOL group: binocular phacoemulsification combin
MIOL group: Binocular phacoemulsification combined with multifocus intraocular lens implantation):None
Age-matched healthy volunteers:None
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients: (1) Aged 50 to 85 years (inclusive), regardless of gender; (2) Meet the diagnostic criteria for bilateral cataracts; (3) Scheduled to undergo bilateral phacoemulsification with intraocular lens implantation; (4) Able and willing to comply with all follow-up schedules; (5) Voluntarily agree to participate in this study and provide written informed consent, unless exemption from written informed consent is approved by the Ethics Committee. 2. Healthy Volunteers: (1) Aged 50 to 85 years (inclusive), regardless of gender; (2) Able and willing to comply with all follow-up schedules; (3) Voluntarily agree to participate in this study and provide written informed consent, unless exemption from written informed consent is approved by the Ethics Committee.
Exclusion criteria
Exclusion criteria: 1. Patients: (1) Systemic diseases that may affect postoperative outcomes, such as patients with unstable blood glucose control due to diabetes; (2) Amblyopia, strabismus, glaucoma, corneal diseases, severe fundus diseases, and other ocular conditions that may affect postoperative outcomes; (3) History of ocular trauma or other ocular surgeries that may confound observation results; (4) Pregnant or lactating women; (5) Current or history of traumatic brain injury, cerebrovascular disease (e.g., stroke), neurological disorders (e.g., epilepsy, dementia, Parkinson's disease), or psychiatric disorders (e.g., depression, schizophrenia); (6) History of alcohol dependence or drug abuse; (7) Symptoms of depression, intellectual disability, dementia, or sleep disorders; (8) Working memory capacity less than 3 or inability to complete working memory tasks; (9) Claustrophobia or metallic implants that do not meet MRI safety standards; (10) Inability to follow up as instructed; (11) Other circumstances deemed by the investigator as unsuitable for patient enrollment. 2. Healthy Volunteers: (1) Systemic diseases that may affect observation results, such as individuals with unstable blood glucose control due to diabetes; (2) Amblyopia, strabismus, corneal diseases, severe fundus diseases, and other ocular conditions that may affect observation results; (3) History of ocular trauma or other ocular surgeries that may confound observation results; (4) Pregnant or lactating women; (5) Current or history of traumatic brain injury, cerebrovascular disease (e.g., stroke), neurological disorders (e.g., epilepsy, dementia, Parkinson's disease), or psychiatric disorders (e.g., depression, schizophrenia); (6) History of alcohol dependence or drug abuse; (7) Symptoms of depression, intellectual disability, dementia, or sleep disorders; (8) Working memory capacity less than 3 or inability to complete working memory tasks; (9) Claustrophobia or metallic implants that do not meet MRI safety standards; (10) Inability to follow up as instructed; (11) Other circumstances deemed by the investigator as unsuitable for volunteer enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Magnetic Resonance Imaging (fMRI);Electroencephalography (EEG); | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in visual acuity, subjective refraction, intraocular pressure, slit-lamp examination, and iTrace examination results compared to pre-operation; | — |
Countries
China
Contacts
Public ContactGuo Tao
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed