Ulcerative Colitis
Conditions
Interventions
Fecal microbiota transplantation group:Intestinal microbiota transplantation (standardized donor) : Routine intestinal antibiotic treatment 3 days before treatment
Polyethylene glycol was routinely administered to clean the intestinal tract 24 hours before transplantation. Colonoscopy or indwelling tube transplantation is performed, with each transplantation con
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged18 to75 years old; 2. Meets the diagnostic criteria for refractory ulcerative colitis as per the "Consensus Opinion on the Diagnosis and Treatment of Inflammatory Bowel Disease (2018, Beijing)," with extensive disease involvement, recurrent episodes, or failure to achieve clinical or endoscopic remission after advanced therapy; 3. Able to independently provide informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of advanced malignancies, severe infectious diseases, or hepatic or renal insufficiency; 2. Presence of contraindications for colonoscopy evaluation; 3. Patients or their families unable to understand the conditions and objectives of this study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Clinical response at week 8 ;Endoscopic remission;Histological remission;Adverse reactions: including but not limited to abdominal distension, abdominal pain, diarrhea, intestinal infection, bloodstream infection, septic shock, etc;Changes in fecal microbiota; | — |
Primary
| Measure | Time frame |
|---|---|
| Clinical remission at week 8 ; | — |
Countries
China
Contacts
Public ContactLi Jingnan
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed