Spinal anesthesia-induced hypotension
Conditions
Interventions
Supine Dose-Escalation Cohort:Up-and-down sequential dose-response trial: Each subject received prophylactic phenylephrine after anesthesia positioning. Initial dose 40µg, subsequent doses adjusted ba
if ineffective, increase by 10µg) until ED90 dose was determined. All subjects received standard preloading (10mL/kg lactated Ringer's solution).
Sponsors
Shanghai First Maternal and Infant Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary participation in the study: All parturients signed informed consent forms. 2. Planned elective cesarean section under spinal anesthesia. 3. Single fetus, gestational age >37 weeks. 4. ASAI or grade II. 5. 18 years < age <45 years
Exclusion criteria
Exclusion criteria: 1. Height 100 kg, or body mass index (BMI)>35 kg/m^2 2. Allergy to norepinephrine 3. Chronic hypertension during pregnancy, gestational hypertension, preeclampsia, eclampsia, and pregnancy-related heart disease 4. Fetal distress, or other fetal abnormalities 5. Supine position syndrome in late pregnancy 6. Contraindications for intrathecal anesthesia: such as coagulation disorders, local anesthetic hypersensitivity, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED90 of prophylactic single-dose phenylephrine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal adverse reactions: nausea, vomiting, chest tightness;Neonatal height and weight;Neonatal Apgar score (1 minute and 5 minutes);Neonatal umbilical cord blood gas analysis (acidosis, etc.);Comparison with previous left lateral positioning study results; | — |
Countries
China
Contacts
Public ContactZhang Yueqi
Shanghai First Maternal and Infant Hospital
Outcome results
None listed