Acquired Immunodeficiency Syndrome
Conditions
Interventions
Oral Semaglutide Group:None
Non-Semaglutide Group:None
Sponsors
Beijing Ditan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Treatment Group (Oral Semaglutide Group): 1.Confirmed HIV-positive status. 2.Currently receiving integrase strand transfer inhibitor (INSTI)–based HAART for more than 6 months. 3.Aged 18–60 years. 4.Undetectable HIV viral load. 5.Body mass index (BMI) >= 24.0 kg/m^² (overweight or obesity). 6.Abnormal glucose metabolism, defined as one of the following: Impaired fasting glucose (IFG): fasting plasma glucose (FPG) 6.1–7.0 mmol/L and 2-hour post–oral glucose load plasma glucose =7.0 mmol/L, or random venous plasma glucose or 2-hour post–oral glucose load plasma glucose >= 11.1 mmol/L, or glycated hemoglobin (HbA1c)>= 6.5%. 7.Receiving oral semaglutide. Control Group (Non-Semaglutide Group): 1.Confirmed HIV-positive status. 2.Currently receiving integrase strand transfer inhibitor (INSTI)–based HAART for more than 6 months. 3.Aged 18–60 years. 4.Undetectable HIV viral load. 5.Body mass index (BMI) >=24.0 kg/m^² (overweight or obesity) 6.Abnormal glucose metabolism, defined as one of the following: Impaired fasting glucose (IFG): fasting plasma glucose (FPG) 6.1–7.0 mmol/L and 2-hour post–oral glucose load plasma glucose =7.0 mmol/L, or random venous plasma glucose or 2-hour post–oral glucose load plasma glucose >= 11.1 mmol/L, or glycated hemoglobin (HbA1c) >= 6.5%. 7.Not receiving oral semaglutide.
Exclusion criteria
Exclusion criteria: 1.Presence of severe primary diseases of the heart, liver, kidney, or hematopoietic system. 2.Pregnancy or lactation, or women of childbearing potential who are unwilling or unable to use effective contraception as required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy Indicators;Inflammatory Markers; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety Indicators; | — |
Countries
China
Contacts
Public ContactXiao Jiang
Beijing Ditan Hospital, Capital Medical University
Outcome results
None listed