Lung cancer
Conditions
Interventions
Sponsors
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with a preoperative diagnosis of non-small cell lung cancer scheduled for elective thoracoscopic surgery under general anesthesia; 2. ASA physical status classification I-III; 3. Age 18-80 years; 4. Voluntary participation and signed informed consent; 5. Agreement to use a postoperative analgesic pump.
Exclusion criteria
Exclusion criteria: 1. Severe cardiopulmonary insufficiency; 2. History of neoadjuvant chemotherapy, targeted therapy, or immunotherapy; 3. Autoimmune disease or chronic inflammation; 4. Systemic infection or corticosteroid use within 1 month prior to surgery; 5. Neutropenia ( 442 µmol/L or undergoing renal replacement therapy); 8. Neuropsychiatric disorders precluding informed consent; 9. Pregnant women; 10. Patients with tumors at other sites or those with metastatic disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum NETosis-Specific Marker (MPO); | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum NETosis-Specific Marker (Citrullinated Histone H3);Inflammatory cytokines (IL-6, IL-8, IL-10);Postoperative pain status; Postoperative recovery quality;Hemodynamic data (intraoperative mean arterial pressure, heart rate);Incidence of PONV within 24 hours postoperatively;hospital stay after operation;Extubation timing and PACU stay duration;Intraoperative Use of Vasoactive Drugs;Incidence of postoperative pulmonary complications and adverse events (including intraoperative awareness; delayed emergence from anesthesia; deep vein thrombosis of the lower extremities; wound infection, etc.).; | — |
Countries
China
Contacts
Public ContactLi Jian
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
Outcome results
None listed