keratoconus
Conditions
Interventions
Control Group:none
Sponsors
Tianjin Medical University Eye Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Experimental Group: 1. Age <30 years, any gender 2. Diagnosed with keratoconus within 2 years (ideally within 1 year) 3. Discontinue wearing contact lenses in the eyes for more than 1 week; Control Group: 1. Age <30 years, any gender 2. Low to moderate myopia, astigmatism < -2.00D 3. Discontinue wearing contact lenses in the eyes for more than 1 week
Exclusion criteria
Exclusion criteria: Experimental Group: 1. Patients with systemic diseases such as autoimmune diseases, connective tissue diseases, or diabetes. 2. Patients with active ocular inflammation or corneal trauma, such as allergic conjunctivitis. 3. Patients with a history of eye surgery, including corneal laser surgery, corneal transplantation, corneal cross-linking surgery, etc. 4. Patients who are pregnant. 5. Patients who have used systemic or local hormonal drugs or anti-inflammatory drugs within the past 3 months. Control Group: Exclusion criteria are the same as those for the experimental group; in addition, patients with a family history of corneal ectasia should also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of related matrix metalloproteinases in tears;sex hormones; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical signs of ocular surface;Central corneal thickness, thinnest corneal thickness, and maximum simulated corneal thickness; | — |
Countries
China
Contacts
Public ContactRuibo Yang
Tianjin Medical University Eye Hospital
Outcome results
None listed