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Determination of ED50 and ED90 effective doses of Oliceridine in elderly patients undergoing radiofrequency ablation surgery for great saphenous vein varicose veins

Determination of ED50 and ED90 effective doses of Oliceridine in elderly patients undergoing radiofrequency ablation surgery for great saphenous vein varicose veins

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600119960
Enrollment
Unknown
Registered
2026-03-06
Start date
2026-03-10
Completion date
Unknown
Last updated
2026-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Varicose veins of the great saphenous vein

Interventions

Experimental group:In this study, the initial dose of oxyryzine was set at 0.02mg/kg, and the ratio of adjacent drug doses was 1.0:1.1. If a positive body movement reaction occurred during the operati
if it was a negative reaction, a randomization of dosage would be conducted, and there was an 89% probability that the dose of oxyryzine would remain unchanged and a 11% probability that it would be i

Sponsors

Anqing Municipal Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age range: 65 - 80 years old; 2. ASA classification: I - III; 3. Patients scheduled to undergo radiofrequency ablation surgery for varicose veins of the great saphenous vein; 4. Voluntary participants in this study and who have signed the informed consent form;

Exclusion criteria

Exclusion criteria: 1. History of abuse of sedative and analgesic drugs; 2. Allergy or intolerance to anesthetic drugs; 3. Patients with hearing or speech impairments who are unable to communicate; 4. Preoperative severe cardiopulmonary dysfunction, liver and kidney dysfunction, uncontrolled hypertension, diabetes or other organ dysfunction; 5. Patients or their family members refuse to participate in the study;

Design outcomes

Primary

MeasureTime frame
Positive motor response;

Secondary

MeasureTime frame
Adverse reactions such as dizziness, nausea and vomiting occurred 24 hours after the operation.;The number of rescue analgesic administrations 24 hours after the operation;Time to get out of bed;Surgery time;Wake-up time;General information (including age, sex, BMI, ASA classification);Oseltamivir fixed dose, total dose of Remazolam;

Countries

China

Contacts

Public ContactXing Wang

Anqing Municipal Hospital

837814231@qq.com+86 152 1298 2636

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026