Mechanical Ventilation
Conditions
Interventions
Observation group :None
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-80 years; 2.Endotracheal intubation and mechanical ventilation; 3.Central venous catheter insertion via the subclavian or internal jugular vein; 4.Patients meeting the 2023 Global Definition of ARDS;
Exclusion criteria
Exclusion criteria: 1.Age 80 years; 2.Patients with obesity (BMI = 35 kg/m²); 3.Pregnant or lactating women; 4.Pulmonary diseases: acute exacerbation of bronchial asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, pleural effusion, pneumothorax, and pulmonary embolism; 5.Cardiac diseases: arrhythmia, valvular regurgitation, cardiac dysfunction (LVEF < 50% or right ventricular dysfunction); 6.Hypernatremia; 7.ECMO treatment; 8.Failure to provide informed consent;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of pulmonary perfusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ventilation-perfusion mismatch percentage;Central venous pressure;Ppeak;Ventilation-perfusion matching percentage;Driving Pressure;Intrapulmonary dead space percentage;Pulmonary shunt percentage;Pplat;PEEPi;Heart rate;Blood pressure;Oxygenation index;Positive end-expiratory pressure;Pmean; | — |
Countries
China
Contacts
Public ContactXiaojing Zou
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed